Comparison of Clinical Outcomes Following One versus Two Stage Hybrid Repair of Thoraco-Abdominal Aortic Aneurysms: A Comprehensive Meta-Analysis

For thoraco-abdominal aortic aneurysms (TAAA), it is unclear whether better to perform hybrid repair in one (single) or two stages (staged). This study aimed compare the clinical outcomes of single vs. staged TAAA. The Medline, Embase, and Cochrane Databases (1 January 1994 11 May 2020) were searched for studies on Cohort case series reporting TAAA eligible inclusion. Newcastle–Ottawa scale an 18 item tool used assess risk bias. primary outcome was 30 day mortality, secondary included post-operative complications, overall survival, other mid term events. A random effects model calculate pooled estimates. total 37 meta-analysis. quality assessment suggested low moderate estimates aneurysm rupture death during stage interval 2% (95% CI 0%–4%, I2 = 0%) 4% 2%–7%, 0%), respectively. Single associated with a significantly higher when compared patients who completed procedures successfully (OR 2.64, 95% 1.36–5.12, 0%). Staged also had lower incidence major adverse cardiac events (MACE) (single: 10%, 5%–16%; staged: 2%, 0%–5%) intestinal complications 15%, 8%–25%; 3%, 1%–6%). outcomes, comparable 12 month related rate re-intervention, graft patency. Two may represent choice controlled rupture, because can provide mortality risks, MACE, as well outcomes. Randomised trials are needed ascertain effect staging elective